Jamie Grefe’s Anatomy Lab is a masterful blend of horror, suspense, and procedural intrigue that will satisfy fans of serial killer and home invasion thrillers. The film opens with a seemingly carefree college sorority pool party, only to quickly spiral into terror as a mysterious serial killer, Bryan, begins targeting four unsuspecting sisters. From the very first scene, the tension is palpable, and the sense of dread lingers throughout the film.
Chris Spinelli delivers a compelling performance as Officer Steve O’Neill, a lawman haunted by memories of a past murder in Idaho, whose investigation gradually uncovers the horrifying truth behind the killings. His procedural approach to the crimes adds a grounded realism to the story, balancing the film’s more shocking and gruesome moments. The supporting cast—Tessa Raine, India Darling, Maggie Peril, and Annabel Storm—bring depth and authenticity to their roles, capturing the mix of sisterly camaraderie, vulnerability, and fear that makes their plight so relatable and compelling.
Visually, Anatomy Lab is striking. Cinematographer Louis DeStefano employs a grindhouse-inspired aesthetic that heightens the suspense and amplifies the horror, while still allowing moments of clarity in the chaos. Each scene is carefully framed to maximize tension, keeping audiences on the edge of their seats. Director Grefe’s pacing is deliberate yet relentless, delivering scares, shocks, and suspense in a way that feels both natural and gripping.
Ultimately, Anatomy Lab is a cold-hearted thriller that grabs viewers from the start and never lets go. With its blend of chilling suspense, stylish cinematography, and strong performances, it is destined to become an instant cult classic among fans of horror, thrillers, and true crime-inspired stories. Jamie Grefe and Gregory Hatanaka have crafted a film that’s both a homage to classic grindhouse terror and a fresh, modern entry into the genre, making it a must-watch for anyone who thrives on high-stakes tension and edge-of-your-seat horror.
Jessie Hobson